Israeli warplanes targeted the home of a senior Hamas military leader in the central Gaza Strip early Monday leaving 42 civilians injured, medics said.

Al-Qassam Brigades leader Alla Ad-Danaf's home in Deir Al-Balah was destroyed along with five others by a missile from an Israeli F16 fighter jet, military medical services coordinator Adham Abu Salmiyya told Ma'an.

At least 42 civilians were injured as a result, he added, with wounds ranging from slight to moderate.

The Israeli army has denied involvement, with an Israeli military spokeswoman saying there was no army or air force activity overnight.

On Saturday morning, an Al-Qassam leader was killed in an Israeli airstrike, which the Israeli army said came in response to projectile fire.

The latest blast follows a weekend of airstrikes across the Gaza Strip, with residents saying the raids were reminiscent of Israel's Operation Cast Lead between December 2008 and January 2009.